Macrocyclics特约代理,Macrocyclics特约代理价格|报价-安诺伦（北京）生物科技有限公司

来自 : 发布时间：2024-05-12

苏州蚂蚁淘生物科技有限公司是一家依托于中科院生命科学领域的高新技术生物公司，致力于生命科学领域产品的研发与销售，蚂蚁淘生物秉承为客户提供高质量产品及优质服务的理念，从事科研机构及生产企业所需的各种品牌生化剂、抗体、血清、ELISA试剂盒、移液枪、中小型仪器设备、耗材等专业进出口公司。主要经营品牌abcam、abnova、peprotech、RD、CST、AbD Serotec、Athens Research Technology、Chemicon 、Evrogen、 Bio-Rad、 Zymed、wako、bachem、Exiqon、Invitrogen、Eppendorf、Bioassay、cayman、TRC、Omega、Promega、Axygen、AssayPro等品牌中国区域.代理商,自成立以来发展迅速，产品服务得到全国广大生产企业、高校、科研院所、医疗系统及相关试剂公司的肯定，我们愿竭尽所能，赛因百奥生物在保证产品质量的基础上将以超低价格为您提供优质服务；同时也为广大经销公司提供充足货源，我们的目标是努力成为国内生物学产品行业专业供应商。

CLIA Kits 化学发光免疫分析(chemiluminescence immunoassay,CLIA)

RNA Interference Products RNA干扰试剂

RNA干扰（RNA interference, RNAi）是指在进化过程中高度保守的、由双链RNA（double-stranded RNA，dsRNA）诱发的、同源mRNA高效特异性降解的现象。基因沉默，主要有转录前水平的基因沉默(TGS)和转录后水平的基因沉默(PTGS)两类:TGS是指由于DNA修饰或染色体异染色质化等原因使基因不能正常转录;PTGS是启动了细胞质内靶mRNA序列特异性的降解机制。有时转基因会同时导致TGS和PTGS。

由于使用RNAi技术可以特异性剔除或关闭特定基因的表达，（长度超过三十的dsRNA会引起干扰素毒性）所以该技术已被广泛用于探索基因功能和传染性疾病及恶性肿瘤的治疗领域。

1.RNAi抑制转座子活性

两方面的证据提示转座子活性的抑制与siRNA有关

① 发现蠕虫mut-7 基因参与RNAi 并且与转座子的转座抑制有关;

② 在果蝇中, 参与RNAi 的RNA 解螺旋酶Spindle-E 的突变将导致该基因引起的基因沉默的缺失, 同时提高了反转录转座子活性。

2.RNAi抵御病毒感染

在拟南芥中研究转基因引起基因沉默时发现, sgs2/sde1基因突变的拟南芥对病毒的侵染表现出高度的敏感性 。

3.RNAi参与异染色质的形成和维持

Hall 等研究表明,着丝粒同源重复序列和RNAi 组分一起正负调节着异染色质的形成并共同促使异染色质组装成核；Vople 等在敲除裂殖酵母( S. pombe) 的RNAi 途径基因( 如Argonaute 、Dicer 、RDRP) 时发现异染色质转录得到的dsRNA可以在RNAi 途径的参与下, 加工成si RNA,si RNA 募集异染色质蛋白1( HP1) , 然后靶向性引起相应异染色质区域的转基因沉默。

4.RNAi参与机体的发育调控及生理代谢

RNAi 只抑制转录后的基因, 所以RNAi 在生物体发育学研究中具有优势。Chuang 等用RNAi 技术进一步证实了AG、CLV3 、AP1 、PAN 等已知功能基因在拟南芥花发育过程中的功能。在RNAi 过程中形成的RISC 复合物可根据不同情况分别利用si RNA 或stRNA 行使不同的功能, 但最终均导致特定基因沉默。

26S Proteasome Complex Subunit SEM1 (SEM1) shRNAabx972681

Specificity:SHFM1 shRNA Plasmid (Mouse) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.

Form:Lyophilized

26S Proteasome Complex Subunit SEM1 (SEM1) shRNAabx955330Specificity:SHFM1 shRNA Plasmid (Human) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.Form:Lyophilized26S Proteasome Complex Subunit SEM1 (SEM1) shRNAabx968127Specificity:C7orf76 shRNA Plasmid (Human) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.Form:Lyophilized26S Proteasome Complex Subunit SEM1 (SEM1) siRNAabx909935Specificity:C7orf76 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.Purity:> 97%Form:Lyophilized

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